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ナノバイオプローブ業績

原著論文

  • Tsuboi, S., Yamada, S., Nakane, Y., Sakata, T., Yasuda, H. & Jin, T.
    "Water-soluble near-infared fluorophores emitting over 1000 nm and their application to in vivo imaging in the second optical window (1000-1400nm)"
    ECS J. Solid State Sci. Technol. 7, R3093-3101 (2018)
  • Tsuboi, S. & Jin, T.
    "Bioluminescence Resonance Energy Transfer (BRET)-coupled AnnexinV-functionalized Quantum Dots for Near-Infrared Optical Detection of Apoptotic Cells"
    ChemBioChem 18, 2231-2235 (2017) doi:10.1002/cbic.201700486
  • Tsuboi, S., Sasaki, A., Sakata, T., Yasuda, H. & Jin, T.
    "Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging"
    Chem. Commun. 53, 9450-9453 (2017) doi:10.1039/c7cc04966h
  • Morishita, Y., Hironaka, K., Lee, S. W., Jin, T. & Ohtsuka, D.
    "Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells"
    Nat. Commun. 8, 15 (2017) doi:10.1038/s41467-017-00023-7
  • Oura, M., Yamamoto, J., Jin, T. & Kinjo, M.
    "Investigation of pH-dependent photophysical properties of quantum nanocrystals by fluorescence correlation spectroscopy"
    Opt. Express 25, 1435-1443 (2017) doi:10.1364/oe.25.001435
  • Nakagawa, J., Matsumoto, N., Nakane, Y., Yamakawa, K., Yamada, T., Matsumoto, H., et al.
    "The beneficial effects of ETS-GS, a novel vitamin E derivative, on a rat model of crush injury"
    Shock 46, 681-687 (2016) doi:10.1097/shk.0000000000000681
  • Imamura, Y., Yamada, S., Tsuboi, S., Nakane, Y., Tsukasaki, Y., Komatsuzaki, A., et al.
    "Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain"
    Molecules 21, 1080 (2016) doi:10.3390/molecules21081080
  • Imamura, Y., Yoshikawa, N., Murkami, Y., Mitani, S., Matsumoto, N., Matsumoto, H., et al.
    "Effect of histone acetylation on N-methyl-D-aspartate 2B receptor subunits and interleukin-1 receptors in association with nociception-related somatosensory cortex dysfunction in a mouse model of sepsis"
    Shock 45, 660-667 (2016) doi:10.1097/shk.0000000000000547
  • Jin, T. & Imamura, Y.
    "Applications of Highly Bright PbS Quantum Dots to Non-Invasive Near-Infrared Fluorescence Imaging in the Second Optical Window"
    Ecs Journal of Solid State Science and Technology 5, R3138-R3145 (2016) doi:10.1149/2.0171601jss
  • Jin, T., Tsuboi, S., Komatsuzaki, A., Imamura, Y., Muranaka, Y., Sakata, T., et al.
    "Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging"
    Med. Chem. Commun 7, 623-631 (2016) doi:10.1039/c5md00580a
  • Takai, A., Nakano, M., Saito, K., Haruno, R., Watanabe, T. M., Ohyanagi, T., et al.
    "Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging"
    Proc. Natl. Acad. Sci. U.S.A. 112, 4352-4356 (2015) doi:10.1073/pnas.1418468112
  • Komatsuzaki, A., Ohyanagi, T., Tsukasaki, Y., Miyanaga, Y., Ueda, M. & Jin, T.
    "Compact Halo-ligand-conjugated quantum dots for multicolored single-molecule imaging of overcrowding GPCR proteins on cell membranes"
    Small 11, 1396-1401 (2015) doi:10.1002/smll.201402508
  • Sasaki, A., Tsukasaki, Y., Komatsuzaki, A., Sakata, T., Yasuda, H. & Jin, T.
    "Recombinant protein (EGFP-Protein G)-coated PbS quantum dots for in vitro and in vivo dual fluorescence (visible and second-NIR) imaging of breast tumors"
    Nanoscale 7, 5115-5119 (2015) doi:10.1039/c4nr06480a
  • Saitoh, Y., Terada, N., Ohno, N., Hamano, A., Okumura, N., Jin, T., et al.
    "Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique"
    Microvasc. Res. 91, 73-83 (2014) doi:10.1016/j.mvr.2013.11.004
  • Tsukasaki, Y., Morimatsu, M., Nishimura, G., Sakata, T., Yasuda, H., Komatsuzaki, A., et al.
    "Synthesis and optical properties of emission-tunable PbS/CdS core-shell quantum dots for in vivo fluorescence imaging in the second near-infrared window"
    RSC Adv. 4, 41164-41171 (2014) doi:10.1039/c4ra06098a
  • Nakane, Y. & Kubo, I.
    "Fluorescence Sensing of the Interaction between Biomembranes with Different Lipid Composition and Endocrine Disrupting Chemicals"
    Materials 7, 170-179 (2014) doi:10.3390/ma7010170
  • Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y. & Jin, T.
    "A short-wavelength infrared emitting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice"
    Chem. Commun. 50, 14356-14359 (2014) doi:10.1039/c4cc06542e
  • Watanabe, T. M., Fujii, F., Jin, T., Umemoto, E., Miyasaka, M., Fujita, H., et al.
    "Four-Dimensional Spatial Nanometry of Single Particles in Living Cells Using Polarized Quantum Rods"
    Biophys. J. 105, 555-564 (2013) doi:10.1016/j.bpj.2013.07.001
  • Tahara, K., Fujimoto, S., Fujii, F., Tozuka, Y., Jin, T. & Takeuchi, H.
    "Quantum Dot-Loaded Liposomes to Evaluate the Behavior of Drug Carriers after Oral Administration"
    J. Pharmaceutics 2013, 6 (2013) doi:10.1155/2013/848275
  • Tanaka, S., Aoki, K., Muratsugu, A., Ishitobi, H., Jin, T. & Inouye, Y.
    "Synthesis of green-emitting Pt-8 nanoclusters for biomedical imaging by pre-equilibrated Pt/PAMAM (G4-OH) and mild reduction"
    Optical Materials Express 3, 157-165 (2013)
  • Hasegawa, M., Tsukasaki, Y., Ohyanagi, T. & Jin, T.
    "Bioluminescence resonance energy transfer coupled near-infrared quantum dots using GST-tagged luciferase for in vivo imaging"
    Chem. Commun. 49, 228-230 (2013) doi:10.1039/c2cc36870f
  • Higashi, K., Jin, T. & Takahashi, E.
    "Oxygen-Sensitive Quantum Dots for Possible Nanoscale Oxygen Imaging in Cultured Cells"
    Adv. Exp. Med. Biol. 789, 379-383 (2013) doi:10.1007/978-1-4614-7411-1_50
  • Nakane, Y., Tsukasaki, Y., Sakata, T., Yasuda, H. & Jin, T.
    "Aqueous synthesis of glutathione-coated PbS quantum dots with tunable emission for non-invasive fluorescence imaging in the second near-infrared biological window (1000-1400 nm)"
    Chem. Commun. 49, 7584-7586 (2013) doi:10.1039/c3cc44000a
  • Wang, H., Imamura, Y., Matsumoto, N., Yoshikawa, N., Nakagawa, J., Yamakawa, K., et al.
    "Matrix Metalloproteinase-9 Triggers the Gap Junction Impairment and Somatosensory Neuronal Dysfunction in Septic Encephalopathy"
    Biochemistry & Pharmacology 2, 108 (2013) doi:10.4172/2167-0501.1000108
  • Ma, Q., Nakane, Y., Mori, Y., Hasegawa, M., Yoshioka, Y., Watanabe, T. M., et al.
    "Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors"
    Biomaterials 33, 8486-8494 (2012) doi:10.1016/j.biomaterials.2012.07.051
  • Nakane, Y., Sasaki, A., Kinjo, M. & Jin, T.
    "Bovine serum albumin-coated quantum dots as a cytoplasmic viscosity probe in a single living cell"
    Anal. Methods 4, 1903-1905 (2012) doi:10.1039/c2ay25318f
  • Ohmachi, M., Komori, Y., Iwane, A. H., Fujii, F., Jin, T. & Yanagida, T.
    "Fluorescence microscopy for simultaneous observation of 3D orientation and movement and its application to quantum rod- tagged myosin V"
    Proc. Natl. Acad. Sci. U.S.A. 109, 5294-5298 (2012) doi:10.1073/pnas.1118472109
  • Saitoh, Y., Terada, N., Saitoh, S., Ohno, N., Jin, T. & Ohno, S.
    "Histochemical analyses and quantum dot imaging of microvascular blood flow with pulmonary edema in living mouse lungs by "in vivo cryotechnique""
    Histochemistry and Cell Biology 137, 137-151 (2012) doi:10.1007/s00418-011-0892-1
  • Ohyanagi, T., Nagahori, N., Shimawaki, K., Hinou, H., Yamashita, T., Sasaki, A., et al.
    "Importance of Sialic Acid Residues Illuminated by Live Animal Imaging Using Phosphorylcholine Self-Assembled Monolayer-Coated Quantum Dots"
    J. Am. Chem. Soc. 133, 12507-12517 (2011) doi:10.1021/ja111201c
  • Miyazaki, J., Kinoshita, S. & Jin, T.
    "Non-radiative exciton recombination through excitation energy transfer in quantum dot clusters"
    J. Lumin. 131, 539-542 (2011) doi:10.1016/j.jlumin.2010.11.006
  • Tiwari, D. K., Jin, T. & Behari, J.
    "Bio-distribution and toxicity assessment of intravenously injected anti-HER2 antibody conjugated CdSe/ZnS quantum dots in Wistar rats"
    Int. J. Nanomed. 6, 463-475 (2011) doi:10.2147/ijn.s15124
  • Tanaka, S., Miyazaki, J., Tiwari, D. K., Jin, T. & Inouye, Y.
    "Fluorescent Platinum Nanoclusters: Synthesis, Purification, Characterization, and Application to Bioimaging"
    Angewandte Chemie-International Edition 50, 431-435 (2011) doi:10.1002/anie.201004907

総説

  • 今村 行雄・神 隆
    「第2光学窓近赤外蛍光プローブによるマウス脳の非侵襲イメージング」
    月刊バイオインダストリー, 2017年1月号
  • 神 隆
    「近赤外生体蛍光イメージング用量子ドット」
    『次世代蛍光体材料の開発』p.159-169, シーエムシー出版 (2016)
  • 神 隆
    「生体の第２光学窓における非侵襲近赤外蛍光イメージング」
    日本レーザー医学会誌, 36, (2), (2015)
  • 神 隆
    「量子ドット蛍光プローブ」
    『発光の事典』朝倉書店 (2015)
  • 渡邉 朋信・市村 垂生・神 隆
    「生体分子動態のナノイメージング」
    光アライアンス, 24, (4), 15-20  (2013)
  • 大柳 達也・神 隆
    「蛍光性半導体量ナノ粒子の合成と医療への応用」
    ケミカルエンジニアリング, 10, 18-25  (2012)
  • 神 隆
    「半導体量子ドット、その合成法と生命科学への応用」
    生産と技術, 63, (2), 58-65  (2011)

書籍

  • Jin, T., Sasaki, A. & Imamura, Y.
    "Smart biomarker-coated PbS quantum dots for deeper near-infrared fluorescence imaging in the second optical window"
    In Shi, L. & Alfano, R.(Eds.) Deep imaging in tissues and biomedical materials. (p.203-220). Pan Stanford Publishing (2017)