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Masujima Lab facility

Primary paper

  • Fujii, T., Matsuda, S., Tejedor, M. L., Esaki, T., Sakane, I., Mizuno, H., et al.
    "Direct metabolomics for plant cells by live single-cell mass spectrometry"
    Nat. Protoc. 10, 1445-1456 (2015) doi:10.1038/nprot.2015.084
  • Shimizu, T., Miyakawa, S., Esaki, T., Mizuno, H., Masujima, T., Koshiba, T., et al.
    "Live Single-Cell Plant Hormone Analysis by Video-Mass Spectrometry"
    Plant and Cell Physiology 56, 1287-1296 (2015) doi:10.1093/pcp/pcv042
  • Emara, S., Masujima, T., Zarad, W., Kamal, M., Fouad, M. & El-Bagary, R.
    "A Combination of Isocratic and Gradient Elution Modes in HPLC with the Aid of Time-Overlapping Process for Rapid Determination of Methyldopa in Human Urine"
    J. Liq. Chromatogr. Related Technol. 38, 153-162 (2015) doi:10.1080/10826076.2014.896813
  • Fujita, H., Esaki, T., Masujima, T., Hotta, A., Kim, S. H., Noji, H., et al.
    "Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry"
    RSC Adv. 5, 16968-16971 (2015) doi:10.1039/c4ra12021c
  • Tsuyama, N., Mizuno, H., Katafuchi, A., Abe, Y., Kurosu, Y., Yoshida, M., et al.
    "Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts"
    Journal of Radiation Research 56, 46-58 (2015) doi:10.1093/jrr/rru078
  • Horiyama, S., Takahashi, Y., Hatai, M., Honda, C., Suwa, K., Ichikawa, A., et al.
    "Methyl Vinyl Ketone, a Toxic Ingredient in Cigarette Smoke Extract, Modifies Glutathione in Mouse Melanoma Cells"
    Chemical & Pharmaceutical Bulletin 62, 772-778 (2014)
  • Mizuno, H., Tsuyama, N. & Masujima, T.
    "Live Single-cell Mass Spectrometry for Organelle Metabolomics"
    Bunseki Kagaku 63, 477-484 (2014)
  • Emara, S., Masujima, T., Zarad, W., Mohamed, K., Kamal, M., Fouad, M., et al.
    "Field-Amplified Sample Stacking beta-Cyclodextrin Modified Capillary Electrophoresis for Quantitative Determination of Diastereomeric Saponins"
    J. Chromatogr. Sci. 52, 1308-1316 (2014) doi:10.1093/chromsci/bmt169
  • Emara, S., Masujima, T., Zarad, W., Kamal, M. & El-Bagary, R.
    "Online Pre-Column Derivatization with Chromatographic Separation to Determine Folic Acid "
    J. Chromatogr. Sci. 51, 544-551 (2013) doi:10.1093/chromsci/bms170
  • Emara, S., Masujima, T., Hadad, G., Kamal, M., ZaaZaa, H. & Kawi, M. A.
    "A rapid, sensitive, and environmentally friendly on-line solid phase extraction using protein-coated mu-bondapak cyanide silica precolumn for chromatographic determination of paracetamol in human serum "
    J. Liq. Chromatogr. Related Technol. 36, 1297-1311 (2013) doi:10.1080/10826076.2012.686139
  • Sasada, S., Miyata, Y., Tsutani, Y., Tsuyama, N., Masujima, T., Hihara, J., et al.
    "Metabolomic analysis of dynamic response and drug resistance of gastric cancer cells to 5-fluorouracil "
    Oncology Reports 29, 925-931 (2013) doi:10.3892/or.2012.2182
  • Fukano, Y., Tsuyama, N., Mizuno, H., Date, S., Takano, M. & Masujima, T.
    "Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry"
    Nanomedicine 7, 1365-1374 (2012) doi:10.2217/nnm.12.34
  • Tsuyama, N., Mizuno, H. & Masujima, T.
    "Molecular and Functional Analysis of Cellular Phenomena Using Single-Cell Mass Spectrometry"
    Biological & Pharmaceutical Bulletin 35, 1425-1431 (2012)
  • Tejedor, M. L., Mizuno, H., Tsuyama, N., Harada, T. & Masujima, T.
    "In Situ Molecular Analysis of Plant Tissues by Live Single-Cell Mass Spectrometry"
    Anal. Chem. 84, 5221-5228 (2012) doi:10.1021/ac202447t
  • Date, S., Mizuno, H., Tsuyama, N., Harada, T. & Masujima, T.
    "Direct Drug Metabolism Monitoring in a Live Single Hepatic Cell by Video Mass Spectrometry"
    Anal. Sci. 28, 201-203 (2012)
  • Emara, S., Masujima, T., Zarad, W., Kamal, M. & EL-Bagary, R.
    "On-line solid-phase enrichment coupled to packed reactor flow injection analysis in a green analytical procedure to determine low levels of folic acid using fluorescence detection "
    Chem. Cent. J. 6 (2012) doi:10.1186/1752-153X-6-155
  • Tsuyama, N., Mizuno, H. & Masujima, T.
    "Mass Spectrometry for Cellular and Tissue Analyses in a Very Small Region "
    Anal. Sci. 27, 163-170 (2011) doi:10.2116/analsci.27.163
  • Tejedor, M. L., Mizuno, H., Tsuyama, N., Harada, T. & Masujima, T.
    "Direct Single-Cell Molecular Analysis of Plant Tissues by Video Mass Spectrometry "
    Anal. Sci. 25, 1053-1055 (2009)
  • Mizuno, H., Tsuyama, N., Harada, T. & Masujima, T.
    "Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification "
    J. Mass Spectrom. 43, 1692-1700 (2008) doi:10.1002/jms.1460

Review

  • Masujima, T.
    "Live Single-cell Mass Spectrometry "
    Anal. Sci. 25, 953-960 (2009)

Presentation (poster)

  • Mizuno, H., Kawai, Y. & Masujima, T.
    "Live Single-cell Mass Spectrometry for Direct Lipid Analysis of a Stimulated Allergy Cell"
    62th ASMS Conference, Baltimore, USA. . Jun 16 - 20, 2014
  • Fujita, A., Mizuno, H., Sakane, I. & Masujima, T.
    "Targetted Analysis of Peptides in Live Single-Cell Mass Spectrometry"
    62th ASMS Conference, Baltimore, USA. Jun 16 - 20, 2014
  • Fujii, T., Esaki, T., Date, S., Mizuno, H. & Masujima, T.
    "Spatial Analysis of Phototropic Metabolites in a Plant Cell by Live Single-cell Mass Spectrometry"
    62th ASMS Conference, Baltimore, USA. Jun 16 - 20, 2014
  • Esaki, T., Date, S., Mizuno, H., Fujita, A. & Masujima, T.
    "Direct Mitochondrial Metabolites Detection in a HepG2 Cell by Live Single-cell Mass Spectrometry"
    62th ASMS Conference, Baltimore, USA. Jun 16 - 20, 2014
  • Takahashi, A., Watanabe, H., Miyasaka, Y., Esaki, T., Mizuno, H. & Masujima, T.
    "Health Sustaining Components Analysis by LC-MS in Heavy Fermented “Miso”"
    62th ASMS Conference, Baltimore, USA. Jun 16 - 20, 2014
  • Tsuyoshi Esaki, Hajime Mizuno, Sachiko Date, Naohiro Tsuyama, Tsutomu Masujima
    "Variety and Specificity of Granules in a Cell, Detected by Live Single-Cell Mass Spectrometry"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Iwao Sakane, Yuko M Sagesaka, Hajime Mizuno, Naohiro Tsuyama, Takanori Harada, Tsutomu Masujima
    "Detecting Substances in Tea Leaves by Live Single-cell Mass Spectrometry"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Shuichi Mastuda, Satomi Hatano-Saga, Sachiko Date, Hajime Mizuno, Naohiro Tsuyama, Tsutomu Masujima
    "Distribution of Metabolites and Biosynthesis in a Cell of a Plant Tissue Analyzed by Live Singlecell Mass Spectrometry"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Sachiko Date, Kiyoko Bando, Jiro Deguchi, Izuru Miyawaki, Juki Kimura, Hitoshi Funabashi, Tsutomu Masujima
    "Evaluation of Mitochondrial Function Based on the Direct Single-Cell Molecular Analysis by Mass Spectrometry"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Ai Fujita, Iwao Sakane, Tsutomu Masujima
    "In-a-tip Omics Using Mass Spectrometer with a Nano-Electrospray Ionization"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Hajime Mizuno, Naohiro Tsuyama, Toshiki Ueda, Sachiko Date, Takanori Harada Tsutomu Masujima
    "Live Single-cell Mass Spectrometry for Direct Cellular Phospholipid Analysis"
    61th ASMS Conference, Minneapolis, USA. Jun 9 - 13, 2013
  • Mizuno, H., Date, S., Tsuyama, N. & Masujima, T.
    "In situ direct live single-cell exhaustive molecular analysis by video-mass spectrometry. "
    Mol. Biol. Cell 23 (2012)