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Laboratory for Physical Biology

Tatsuo Shibata


Team Leader

Tatsuo Shibata (Ph.D.)


Original HP

Advances in measurement technologies have afforded us glimpses into dynamic functional processes, such as morphogenesis and information processing, in cells and tissues involved in development and regeneration. The truly organic dynamism of the biological phenomena exhibited by living cells, individually or in groups, emerges from the coordinated interaction of numerous molecular and genetic factors, and the need for integrated, systems-based approaches to the study of design and operating principles in such “living” phenomena is becoming increasingly clear. This will require not only technologies for the measurement of such elements but the development of applicable mathematical methods as well. In Laboratory for Physical Biology, we will seek to use concepts and methodology from mathematical sciences such as physics in the study and elucidation of these emerging questions in biology.

Research Topics

  • Dynamics of information processes of chemotaxis
  • Dynamics of polarization
  • Dynamics of gene regulatory networks

Selected Publications

  • Wen, F. L., Wang, Y. C. & Shibata, T.
    "Epithelial Folding Driven by Apical or Basal-Lateral Modulation: Geometric Features, Mechanical Inference, and Boundary Effects"
    Biophys. J. 112, 2683-2695 (2017) doi:10.1016/j.bpj.2017.05.012
  • Sato, K., Hiraiwa, T., Maekawa, E., Isomura, A., Shibata, T. & Kuranaga, E.
    "Left–right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis"
    Nat. Commun. 6, 10074 (2015) doi:10.1038/ncomms10074
  • Sato, K., Hiraiwa, T. & Shibata, T.
    "Cell Chirality Induces Collective Cell Migration in Epithelial Sheets"
    Phys. Rev. Lett. 115, 188102 (2015) doi:10.1103/PhysRevLett.115.188102
  • Hiraiwa, T., Nagamatsu, A., Akuzawa, N., Nishikawa, M. & Shibata, T.
    "Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis"
    Phys. Biol. 11, 056002 (2014) doi:10.1088/1478-3975/11/5/056002
  • Nishikawa, M., Horning, M., Ueda, M. & Shibata, T.
    "Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis"
    Biophys. J. 106, 723-734 (2014) doi:10.1016/j.bpj.2013.12.023
  • Shibata, T., Nishikawa, M., Matsuoka, S. & Ueda, M.
    "Intracellular Encoding of Spatiotemporal Guidance Cues in a Self-Organizing Signaling System for Chemotaxis in Dictyostelium Cells"
    Biophys. J. 105, 2199-2209 (2013) doi:10.1016/j.bpj.2013.09.024
  • Inomata, H., Shibata, T., Haraguchi, T. & Sasai, Y.
    "Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Spemann's Organizer Signals"
    Cell 153, 1296-1311 (2013) doi:10.1016/j.cell.2013.05.004
  • Hiraiwa, T., Baba, A. & Shibata, T.
    "Theoretical model for cell migration with gradient sensing and shape deformation"
    Eur. Phys. J. E 36, 32, 9 (2013) doi:10.1140/epje/i2013-13032-1
  • Baba, A., Hiraiwa, T. & Shibata, T.
    "Directional sensing of deformed cells under faint gradients"
    Phys. Rev. E 86, 060901, 5 (2012) doi:10.1103/PhysRevE.86.060901
  • Shibata, T., Nishikawa, M., Matsuoka, S. & Ueda, M.
    "Modeling the self-organized phosphatidylinositol lipid signaling system in chemotactic cells using quantitative image analysis"
    J. Cell Sci. 125, 5138-5150 (2012) doi:10.1242/jcs.108373