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Laboratory for Integrated Biodevice

Yo Tanaka


Unit Leader

Yo Tanaka (Ph.D.(Eng.))

Tanaka of Riken

Original HP

This laboratory aims to promote integration and sophistication of biological experiments using micro structures and channels based on semiconductor fabrication methods. These sizes are near the size of hair or mosquito needle width (10~100 μm) or less. By exploiting these devices to chemical or biological fields, precise cell or molecular handling can be realized. Furthermore, our group focuses on unique functions of cells or tissue of living creatures. By combining this with microfabrication technology, we aim to new functional devices and propose future ideal machine models.

Research Topics

  • Integrated and sophisticated biological experiments
  • Single molecule synthesis, separation, and design
  • Artificial cell creation using micro- and nano-scale technologies
  • Novel micro- and nano-size biological devices

Selected Publications

  • Yalikun, Y. & Tanaka, Y.
    "Ultra-thin glass sheet integrated transparent diaphragm pressure transducer"
    Sensors and Actuators A: Physical 263, Pages 102-112doi:10.1016/j.sna.2017.05.047
  • Tanaka, N., Yamashita, T., Sato, A., Vogel, V. & Tanaka, Y.
    "Simple agarose micro-confinement array and machine-learning-based classification for analyzing the patterned differentiation of mesenchymal stem cells"
    PLoS One 12, e0173647 (2017) doi:10.1371/journal.pone.0173647
  • Tanaka, Y., Noguchi, Y., Yalikun, Y. & Kamamichi, N.
    "Earthworm muscle driven bio-micropump"
    Sensors and Actuators B-Chemical 242, 1186-1192 (2017) doi:10.1016/j.snb.2016.09.123
  • Tanaka, Y., Funano, S. I., Nishizawa, Y., Kamamichi, N., Nishinaka, M. & Kitamori, T.
    "An electric generator using living Torpedo electric organs controlled by fluid pressure-based alternative nervous systems"
    Sci. Rep. 6, 25899 (2016) doi:10.1038/srep25899
  • Funano, S., Tanaka, N. & Tanaka, Y.
    "Vapor-based micro/nano-partitioning of fluoro-functional group immobilization for long-term stable cell patterning"
    RSC Adv. 6, 96306-96313 (2016) doi:10.1039/c6ra16906f
  • Tanaka, N., Moriguchi, H., Sato, A., Kawai, T., Shimba, K., Jimbo, Y., et al.
    "Microcasting with agarose gel via degassed polydimethylsiloxane molds for repellency-guided cell patterning"
    RSC Adv. 6, 54754-54762 (2016) doi:10.1039/c6ra11563b
  • Yalikun, Y., Hosokawa, Y., Iino, T. & Tanaka, Y.
    "An all-glass 12 µm ultra-thin and flexible microfluidic chip fabricated by femtosecond laser processing"
    Lab Chip 16, 2427-2433 (2016) doi:10.1039/c6lc00132g
  • Tanaka, Y. & Fujita, H.
    "Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure"
    Sensors and Actuators B-Chemical 210, 267-272 (2015) doi:10.1016/j.snb.2014.12.069
  • Moriguchi, H., Kawai, T. & Tanaka, Y.
    "Simple bilayer on-chip valves using reversible sealability of PDMS"
    RSC Adv. 5, 5237-5243 (2015) doi:10.1039/c4ra10300a
  • Tanaka, Y.
    "Electric actuating valves incorporated into an all glass-based microchip exploiting the flexibility of ultra thin glass"
    RSC Adv. 3, 10213-10220 (2013) doi:10.1039/c3ra41218k