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Controlling the body clock

Dec 23, 2016

Scheme of Cry1 knock in

A new study from the laboratory of Hiroki Ueda at the RIKEN Quantitative Biology Center investigates circadian timekeeping with a novel approach to creating genetic knock-out rescue mice. Published in Molecular Cell, the study shows how this technique was used to quickly create numerous mouse lines, each with different mutations in a circadian regulator called CRY1. Studying each mutation and the effects on behavior showed that specific changes to the protein affected the duration of the circadian period.

  1. K. L. Ode, H. Ukai, E. A. Susaki, et al.: "Knockout-rescue embryonic stem cell-derived mouse reveals circadian-period control by quality and quantity of CRY1" Molecular Cell DOI: 10.1016/j.molcel.2016.11.022