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| Date of Birth |
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September 9, 1975 |
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| Affiliation |
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Center for Developmental Biology, RIKEN
Laboratory for Systems Biology, Functional Genomics Unit |
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| Academic Degree |
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M.D. and Ph.D. |
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Address
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2-2-3 Minatojima-minamimachi, Chuo-ku,Kobe, Hyogo
650-0047, Japan
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| Education |
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2000 M. D., University of Tokyo, Faculty of Medicine
2007 Ph. D., Department of Pharmacology, Graduate School of Medicine,
The University of Tokyo
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| Research Experiences |
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April, 1997~March, 1998
Lab. of Developmental Biology (Masami Horikoshi's Lab), Institute of Molecular and Cellular Biosciences,
The University of Tokyo: Student Trainee
April, 1998~March, 1999
Sony Computer Science Laboratories: Research Assistant
April, 1999~March, 2000
ERATO Kitano Symbiotic Project: Research Assistant
April, 1999~March, 2000
Yamanouchi Pharmaceutical Co., Ltd.: Technical Staff
April, 2000~March, 2001
Yamanouchi Pharmaceutical Co., Ltd.: Researcher
April, 2001~March, 2002
Yamanouchi Pharmaceutical Co., Ltd.: Postdoctoral Fellow
June, 2001~July, 2002
2001 Complex Systems Summer Schools at Santa Fe Institute, New Mexico, USA.
April, 2002~ March, 2004
Systems Biology Group, NEDO project, Yamanouchi Pharmaceutical Co., Ltd. Group Leader
April, 2003~Present
Laboratory for Systems Biology, Center for Developmental Biology, RIKEN. Laboratory Head
October, 2004~ Present
Functional Genomics Subunit, Center for Developmental Biology, RIKEN. Subunit Leader
April, 2005~ 2006
Tohoku University, Visiting Professor
April, 2005~ Present
Tokushima University, Visiting Professor
April, 2006~ Present
Osaka University, Invited Professor(Biology)
April, 2009~ Present
Kyoto University, Invited Professor (Mathematics)
April, 2010~ Present
National Institute of Genetics, Visiting Professor
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| Awards |
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2001. Japanese Drosophila Research Conference/Moriwaki-Daigoro, Atamasukkiri Award
2002. Sleep Research Society, SRBR Joint Meeting Travel Award
2004. Japan Innovator Award, (Nikkei Business Publications Inc.,)
2005. Tokyo Techno-Forum 21, Gold medal
2006. Young Scientist Award (Ministry of Education, Culture, Sports, Science and Technology)
2006. Genome Technology "Tomorrow's PI Award"
2007. 5th Young Investigator Promotion Awards (Japanese Society for Chronobiology)
2009. IBM Science Award
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| Others |
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Member of the 1st participants from Japan of the 53rd Meeting of Nobel Laureates in Lindau (2003)
Member of the EU inspectorate of G-Tec(Global Technology Comparison), CRDS (Center for Research and Development Strategy), JST (Japan Science and Technology Agency) (2005)
Member of the governing board of JAFoE (Japan-America Frontiers of Engineering) Symposium (2006)
Co-organizer of the International workshop on Synthetic biology "synthetic approaches to cellular functions" (2006)
Co-organizer of the CDB Symposium 2006 "Logic of Development: New Strategies and Concepts" (2006)
Member of the working group for educational programs by young researchers in the ethical committee of MBSJ (Molecular Biology Society of Japan) (2007)
Chair of The Gordon Research Conference on Chronobiology (2007)
Speaker of The 1st JFFoS (Japanese-French Frontiers of Science) Symposium (2007)
Chair of The 10th JAFoS (Japanese-American Frontiers of Science) Symposium (2007)
Member of the governing board of The 2nd JFFoS (Japanese-French Frontiers of Science) Symposium (2008)
Program Committee of the SRBR (Society for Research on Biological Rhythms) (2008)
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| Original Papers |
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Yota B. Kiyohara, Keigo Nishii, Maki Ukai-Tadenuma, Hiroki R. Ueda*, Yasuo Uchiyama and Kazuhiro Yagita, "Detection of a circadian enhancer in the mDbp promoter using prokaryotic 5 transposon vector-based strategy" Nucleic Acids Research, Mar;36(4):e23. 2008
Nobuhiro Nakao, Hiroko Ono, Takashi Yamamura, Tsubasa Anraku, Tsuyoshi Takagi, Kumiko Higashi, Shinobu Yasuo, Yasuhiro Katou, Saburo Kageyama, Yumiko Uno, Takeya Kasukawa, Masayuki Iigo, Peter J. Sharp, Atsushi Iwasawa, Yutaka Suzuki, Sumio Sugano, Teruyuki Niimi, Makoto Mizutani, Takao Namikawa, Shizufumi Ebihara, Hiroki R. Ueda* & Takashi Yoshimura "Thyrotrophin in the pars tuberalis triggers photoperiodic response" Nature 452, 317-322 (20 March 2008)
Hideki Ukai, Tetsuya J. Kobayashi Mamoru Nagano, Koh-hei Masumoto Mitsugu Sujino, Takao Kondo, Kazuhiro Yagita, Yasufumi Shigeyoshi and Hiroki R. Ueda* "Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks", Nature Cell Biology , 2007
Akira Matsumoto*, Maki Ukai-Tadenuma, Rikuhiro G. Yamada, Jerry Houl, Kenichiro D. Uno, Takeya Kasukawa, Brigitte Dauwalder, Taichi Q. Itoh, Kuniaki Takahashi, Ryu Ueda, Paul E. Hardin, Teiichi Tanimura and Hiroki R. Ueda* "A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock" Genes and Development, 21, 1687-1700, 2007 * corresponding authors
Akiko Tsumura, Tomohiro Hayakawa, Yuichi Kumaki, Shin-ichiro Takebayashi, Morito Sakaue, Chisa Matsuoka, Kunitada Shimotohno, Fuyuki Ishikawa, En Li, Hiroki R. Ueda, Jun-ichi Nakayama and Masaki Okano, "Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b" Genes to Cells, 11, 805-814, 2006
Yota B. Kiyohara, Sayaka Tagao, Filippo Tamanini, Akira Morita, Yukiko Sugisawa, Maya Yasuda, Iori Yamanaka, Hiroki R. Ueda, Gijsbertus T.J. van der Horst, Takao Kondo and Kazuhiro Yagita, "The BMAL1 C-terminus regulates the circadian transcription feedback loop" PNAS, 103, 10074-10079, 2006
Trey K. Sato, Rikuhiro G. Yamada, Hideki Ukai, Julie E. Baggs, Loren J. Miraglia, Tetsuya J. Kobayashi, David K. Welsh, Steve A. Kay, Hiroki R. Ueda* and John B. Hogenesch*, "Requirement for Feedback Repression in Mammalian Circadian Clock Function" Nature Genetics, 38, 312-319, 2006 * corresponding authors
Kazuki Kurimoto,Yukuhiro Yabuta,Yasuhide Ohinata,Yukiko Ono,Kenichiro D.Uno,Rikuhiro G.Yamada,Hiroki R.Ueda and Mitinori Saitou. "An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis" Nucleic Acids Research, 34, e42, 2006
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Hiroki R. Ueda, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), "The transcriptional landscape of the mammalian genome" Science, 309, 1559-1563, 2005.
Hiroki R. Ueda, Satoko Hayashi, Wenbin Chen, Motoaki Sano, Masayuki Machida, Yasufumi Shigeyoshi, Masamitsu Iino & Seiichi Hashimoto. "System-level Identification of Transcriptional Circuits Underlying Mammalian Circadian Clocks" Nature Genetics, 37, 187-192, 2005.
Hiroki R. Ueda, Wenbin Chen, Yoichi Minami, Sato Honma, Kenichi Honma, Masamitsu Iino & Seiichi Hashimoto. "Molecular-Timetable Methods for Detection of Body Time and Rhythm Disorders from Single-time-point Genome-wide Expression Profiles" PNAS, 101, 11227-11232, 2004.
Hiroki R. Ueda, Satoko Hayashi, Shinichi Matsuyama, Tetsuya Yomo, Seiichi Hashimoto, Steve A. Kay, John B. Hogenesch, and Masamitsu Iino. "Universality and flexibility in gene expression from bacteria to human" PNAS, 101, 3765-3769, 2004.
Hiroki R. Ueda, Wenbin Chen, Akihito Adachi, Hisanori Wakamatsu, Satoko Hayashi, Tomohiro Takasugi, Mamoru Nagano, Kenichi Nakahama, Yutaka Suzuki, Sumio Sugano, Masamitsu Iino, Yasufumi Shigeyoshi and Seiichi Hashimoto. "A transcription factor response element for gene expression during circadian night" Nature, 418, 534-539, 2002.
Hiroki R. Ueda, Akira Matsumoto, Miho Kawamura, Masamitsu Iino, Teiichi Tanimura and Seiichi Hashimoto. "Genome-wide transcriptional orchestration of circadian rhythms in Drosophila" J. Biol. Chem., 277, 14048-14052, 2002.
Hiroki R. Ueda, Kenzo Hirose and Masamitsu Iino. "Intercellular Coupling Mechanism for Synchronized and Noise-Resistant Circadian Oscillators" J. Theor. Biol., 216, 501-512, 2002.
Hiroki R. Ueda, Masatoshi Hagiwara and Hiroaki Kitano, "Robust Oscillations within the Interlocked Feedback Model of Drosophila Circadian Rhythm" J. Theor. Biol., 210, 401-406, 2001.
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| Reviews |
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Hiroki R. Ueda, "Systems biology flowering in the plant clock field". Mol. Syst. Biol. 2, 60, 2006
Kenichiro Uno and Hiroki R. Ueda "Microarrays: Quality Control and Hybridization Protocol", Circadian Rhythms: Methods And Protocols (Methods in Molecular Biology (Clifton, N.J. ), V.362.) Humana Press; 225-244, 2006
Rikuhiro Yamada and Hiroki R. Ueda "Microarrays: Statistical Methods for Circadian Rhythms" Circadian Rhythms: Methods And Protocols (Methods in Molecular Biology (Clifton, N.J. ), V.362.) Humana Press; 245-264, 2006
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