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国立研究開発法人理化学研究所 生命機能科学研究センター 先端バイオイメージング研究チーム

業績一覧

原著論文解説論文著書

原著論文

2018年

"Cell type discrimination based on image features of molecular component distribution"
Arno Germond, Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Tomonobu M. Watanabe, Hideaki Fujita
Scientific Reports 8, doi:10.1038/s41598-018-30276-1 (Aug. 2018)

"Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli"
Arno Germond, Taro Ichimura, Takaaki Horinouchi, Hideaki Fujita, Chikara Furusawa, Tomonobu M. Watanabe
Communication Biology, doi:10.1038/s42003-018-0093-8 (Jul. 2018)

"Validation of Common Housekeeping Genes as Reference for qPCR Gene Expression Analysis During iPS Reprogramming Process"
Yulia Panina, Arno Germond, Tomonobu M. Watanabe
Scientific Reports 8, Article number: 8716, doi:10.1038/s41598-018-26707-8 (Jun. 2018)

2017年

"Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation"
Kangmin He, Tsuyoshi Sakai, Yoshikazu Tsukasaki, Tomonobu M. Watanabe & Mitsuo Ikebe
Scientific Reports 7, Article number: 13685, doi:10.1038/s41598-017-06147-6 (Oct. 2017)

"The use of a genetically encoded molecular crowding sensor in various biological phenomena"
Hiroaki Machiyama, Takamitsu J. Morikawa, Kazuko Okamoto, Tomonobu M. Watanabe and Hideaki Fujita
Biophysics and Physicobiology, doi: 10.2142/biophysico.14.0_119 (Aug. 2017)

"In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis"
Hide A. Konishi, Suguru Asai, Tomonobu M. Watanabe & Shige H. Yoshimura
Scientific Reports 7, Article number: 5709, doi:10.1038/s41598-017-05959-w (Jul. 2017)

"Raman spectroscopy as a tool for ecology and evolution"
Germond A, Kumar V, Ichimura T, Moreau J, Furusawa C, Fujita H, Watanabe TM.
J. R. Soc. Interface, doi:10.1098/rsif.2017.0174. (Jun. 2017)

"A novel c-Src recruitment pathway from the cytosol to focal adhesions"
Machiyama H, Yamaguchi T, Watanabe TM, Fujita H.
FEBS Lett., doi:10.1002/1873-3468.12696 (May. 2017)

"Human Myosin VIIa Is a Very Slow Processive Motor Protein on Various Cellular Actin Structures"
Sato O, Komatsu S, Sakai T, Tsukasaki Y,
Tanaka R, Mizutani T, Watanabe TM, Ikebe R, Ikebe M.
J Biol Chem., doi:10.1038/srep43569 (May. 2017)

"Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions"
Sato O, Jung HS, Komatsu S, Tsukasaki Y, Watanabe TM, Homma K, Ikebe M.
Scientific Reports 7, Article number: 44237, doi: 10.1038/srep44237 (Mar. 2017)

"Protein expression guided chemical profiling of living cells by the simultaneous observation of Raman scattering and anti-Stokes fluorescence emission"
Liang-da Chiu, Taro Ichimura, Takumasa Sekiya, Hiroaki Machiyama, Tomonobu Watanabe, Hideaki Fujita, Takeaki Ozawa & Katsumasa Fujita
Scientific Reports 7, Article number: 43569, doi:10.1038/srep43569 (Mar. 2017)

2016年

"Non-label immune cell state prediction using Raman spectroscopy"
Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama,  
Tomoyuki Yamaguchi, Tomonobu M. Watanabe & Hideaki Fujita
Scientific Reports 6, Article number: 37562, doi:10.1038/srep37562 (Nov. 2016)

"Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots"
Taishi Kakizuka, Keigo Ikezaki, Junichi Kaneshiro, Hideaki Fujita, Tomonobu M. Watanabe, Taro Ichimura
Biomedical Optics Express,Vol. 7, No. 7, pp. 2475-2493, doi: 10.1364/BOE.7.002475 (Jun. 2016)

"Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it"
Takamitsu J. Morikawa, Hideaki Fujita, Akira Kitamura, Takashi Horio, Johtaro Yamamoto, Masataka Kinjo, Akira Sasaki, Hiroaki Machiyama, Keiko Yosizawa, Taro Ichimura, Katsumi Imada, Takeharu Nagai, Tomonobu M. Watanabe
Scientific Reports 6, Article number: 22342, doi:10.1038/srep22342 (Mar. 2016)

"Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy"
Junichi Kaneshiro, Tomonobu. M. Watanabe, Hideaki Fujita, Taro Ichimura
Applied Optics, 55(5), 1082-1089, doi:10.1364/AO.55.001082 (Jan. 2016)

2015年

"SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane"
Hiroaki Machiyama, Tomoyuki Yamaguchi, Yasuhiro Sawada, Tomonobu M. Watanabe, Hideaki Fujita
FEBS Journal, 282(20), 4034-4055, doi:10.1111/febs.13404 (Sep. 2015)

"Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging"
Kohsuke Gonda, Minoru Miyashita, Hideo Higuchi, Hiroshi Tada, Tomonobu M. Watanabe, Mika Watanabe, Takanori Ishida, Noriaki Ohuchi
Scientific Reports 5, Article number: 14322, doi:10.1038/srep14322 (Sep. 2015)

"Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging"
Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Satoshi Kawata, Tomonobu M. Watanabe, Hideaki Fujita
Scientific Reports, 5, Article number: 11358, doi:10.1038/srep11358 (Jun. 2015)

"Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes"
Hanae Shimo, Satya Nanda Vel Arjunan, Hiroaki Machiyama, Taiko Nishino, Makoto Suematsu, Hideaki Fujita, Masaru Tomita, Koichi Takahashi
PLoS Comput. Biol., 11(6): e1004210. doi:10.1371 (Jun. 2015)

"Gene dynamics of core transcription factors for pluripotency in embryonic stem cells"
Brit G. David, Kazuko Okamoto, Taishi Kakizuka, Taro Ichimura, Tomonobu M. Watanabe, Hideaki Fujita
J. Biosci. Bioeng., 119(4), 406-409. (Apr. 2015)

"Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry"
Hideaki Fujita, Tsuyoshi Esaki, Tsutomu Masujima, Akitsu Hotta, Soo Hyeon Kim, Hiroyuki Noji, Tomonobu M. Watanabe
RSC Adv., 5, 16968-16971. (Jan. 2015)

"Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure"
Yo Tanaka, Hideaki Fujita
Sensors and Actuators B: Chemical, 210, 267-272. (Jan. 2015)

2014年

"Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration"
Hiroaki Machiyama, Hiroaki Hirata, Xia Kun Loh, Madhu Mathi Kanchi, Hideaki Fujita, Song Hui Tan, Keiko Kawauchi, Yasuhiro Sawada
J. Cell. Sci., 127 (16), 3440-3450. (Jun. 2014)

"Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers"
Sayaka Higuchi, Tomonobu M. Watanabe, Keiko Kawauchi, Taro Ichimura, Hideaki Fujita
J Biosci Bioeng., 117(6), 749-755 (Jun. 2014)

"Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis"
Etsuo A. Susaki, Kazuki Tainaka, Dimitri Perrin, Fumiaki Kishino, Takehiro Tawara, Tomonobu M. Watanabe, Chihiro Yokoyama, Hirotaka Onoe, Megumi Eguchi, Shun Yamaguchi, Takaya Abe, Hiroshi Kiyonari, Yoshihiro Shimizu, Atsushi Miyawaki, Hideo Yokota, Hiroki R. Ueda
Cell, 157(3), 726-739 (Apr. 2014)

"Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation"
Akira Ito, Yasunori Yamamoto, Masanori Sato, Kazushi Ikeda, Masahiro Yamamoto, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira
Scientific Reports, 4:4781. doi:10.1038/srep04781 (Apr. 2014)

"Direct evidence of polar nature of ferroelastic twin boundaries in CaTiO3 obtained by second harmonic generation microscope"
Hiroko Yokota, H. Usami, R. Haumont, P. Hicher, Junichi Kaneshiro, E. K. H. Salje, Yoshiaki Uesu
Phys. Rev., B 89(14), 144109 (Apr. 2014)

"Visualizing Cell State Transition Using Raman Spectroscopy"
Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Satoshi Kawata, Tomonobu M. Watanabe, Toshio Yanagida, Hideaki Fujita
PLoS One, 9(1), e84478 (Jan. 2014)

2013年

"Tip-enhanced nano-Raman analytical imaging of locally induced strain distribution in carbon nanotubes"
Taka-aki Yano, Taro Ichimura, Shota Kuwahara, Fekhra H’Dhili, Kazumasa Uetsuki, Yoshito Okuno, Prabhat Verma, and Satoshi Kawata
Nature Communications 4, 2592 (Oct. 2013)

"Metabolic flux analysis of genetically engineered Saccharomyces cerevisiae that produces lactate under micro-aerobic conditions"
Eiji Nagamori, Kazunori Shimizu, Hideaki Fujita, Kenro Tokuhiro, Nobuhiro Ishida, Haruo Takahashi
Bioprocess Biosyst Eng., 36(9), 1261-1265 (Sep. 2013)

"Glycine Insertion Makes Yellow Fluorescent Protein Sensitive to Hydrostatic Pressure"
Tomonobu M. Watanabe, Katsumi Imada, Keiko Yoshizawa, Masayoshi Nishijima, Chiaki Kato, Fumiyoshi Abe, Takamitsu J. Morikawa, Miki Kinoshita, Hideaki Fujita, Toshio Yanagida
PLoS ONE, 8(8), e73212 (Aug. 2013)

"Four-Dimensional Spatial Nanometry of Single Particles in Living Cells Using Polarized Quantum Rods"
Tomonobu M. Watanabe, Fumihiko Fujii, Takashi Jin, Eiji Umemoto, Masayuki Miyasaka, Hideaki Fujita, Toshio Yanagida
Biophysical Journal, 105(3), 555-564 (Aug. 2013)

"Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement"
Masami Yamada, Kanako Kumamoto, Shintaro Mikuni, Yoshiyuki Arai, Masataka Kinjo, Takeharu Nagai, Yoshikazu Tsukasaki, Tomonobu M Watanabe, Mitsuru Fukui, Mingyue Jin, Shiori Toba, Shinji Hirotsune
Nature Communications 4, 2033 (Jun. 2013)

"Far-field free tapping-mode tip-enhanced Raman microscopy"
Jun Yu, Yuika Saito, Taro Ichimura, Satoshi Kawata, Prabhat Verma
Applied Physics Letters, 102(12), 123110 (Mar. 2013)

"Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells"
Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim,Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita
J Biosci Bioeng, 115(3), 320-325 (Mar. 2013)

"Improving spinning disk confocal microscopy by preventing pinhole cross-talk for intravital imaging"
Togo Shimozawa, Kazuo Yamagata, Takefumi Kondo, Shigeo Hayashi, Atsunori Shitamukai, Daijiro Konno, Fumio Matsuzaki, Jun Takayama, Shuichi Onami, Hiroshi Nakayama, Yasuhito Kosugi, Tomonobu M. Watanabe, Katsumasa Fujita, Yuko Mimori-Kiyosue
PNAS, 110(9), 3399-3404 (Feb. 2013)

"Fed-batch system for cultivating genetically engineered yeast that produces lactic acid via the fermentative promoter"
Eiji Nagamori, Hideaki Fujita, Kazunori Shimizu, Kenro Tokuhiro, Nobuhiro Ishida, Haruo Takahashi
J Biosci Bioeng, 115(2), 193-195 (Feb. 2013)

2012年

"Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors"
Qiang Ma, Yuko Nakane, Yuki Mori, Miyuki Hasegawa, Yoshichika Yoshioka, Tomonobu M.Watanabe, Kohsuke Gonda, Noriaki Ohuchi, Takashi Jin
Biomaterials, 33(33), 8486-8494 (Nov. 2012)

"Distinct modulated pupil function system for real-time imaging of living cells"
Tomonobu M.Watanabe, Yoshikazu Tsukasaki, Hideaki Fujita, Taro Ichimura, Tatsuya Saitoh, Shizuo Akira, Toshio Yanagida
PLoS One, 7(9), e44028 (Sep. 2012)

"Engineering strain-sensitive yellow fluorescent protein"
Taro Ichimura, Hideaki Fujita, Keiko Yoshizawa, Tomonobu M.Watanabe
Chemical Communications, 48(63), 7871-7873 (Aug. 2012)

"p130Cas-dependent actin remodelling regulates myogenic differentiation"
Keiko Kawauchi, Wee Wee Tan, Keigo Araki, Farhana Binte Abu Bakar, Minsoo Kim, Hideaki Fujita, Hiroaki Hirata, Yasuhiro Sawada
Biochem J., 445(3), 323-332 (Aug. 2012)

"Atg9 vesicles are an important membrane source during early steps of autophagosome formation"
Hayashi Yamamoto, Soichiro Kakuta, Tomonobu M.Watanabe, Akira Kitamura, Takayuki Sekito, Chika Kondo-Kakuta, Rie Ichikawa, Masataka Kinjo, Yoshinori Ohsumi
Journal of Cell Biology, 198(2), 219-233 (Jul. 2012)

"Subnanometric stabilization of plasmon-enhanced optical microscopy"
Taka-aki Yano, Taro Ichimura, Shota Kuwahara, Prabhat Verma, Satoshi Kawata
Nanotechnology, 23(20), 205503 (May, 2012)

"Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts"
Tomonobu M.Watanabe, Sayaka Higuchi, Keiko Kawauchi, Yoshikazu Tsukasaki, Taro Ichimura, Hideaki Fujita
Biochem. Biophys. Res. Commun., 418(4), 742-747 (Feb. 2012)

解説論文

2017年

文誌混雑を測る蛍光タンパク質"GimRET"
渡邉朋信、藤田英明
生化学 第89巻第4号, pp577-586 (Aug. 25 2017)

2016年

偏光分解光学イメージングのための高速偏光制御システム
金城純一、渡邉朋信、市村垂生
分光研究 Vol65, No. 4, pp207-209 (Aug. 15 2016)

"Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters"
Arno Germond, Hideaki Fujita, Taro Ichimura, Tomonobu M. Watanabe
BIOPHYSICAL REVIEWS, pp1-18, doi:10.1007/s12551-016-0195-9(29 Apr. 2016)

ラマン散乱スペクトルによる細胞指紋法の提案
渡邉朋信、市村垂生、藤田英明
BIO INDUSTRY, Vol.33, No.2, 19-25 (Feb. 2016)

2015年

局在表面プラズモンを利用した超解像顕微分光とイメージング
市村垂生、矢野隆章
分光研究 Vol64, No. 6, pp582-598 (Dec. 2015)

細胞状態を示す指紋 細胞からのラマンスペクトル
藤田英明、市村垂生、渡邉朋信
現代化学 11, No.536, 36-40 (Oct. 2015)

2014年

ラマン顕微鏡による細胞状態の計測
市村垂生
生物物理, vol. 54(6), 315-317, DOI:10.2142/biophys.54.315 (Nov. 2014)

定量生物学推進に向けた先端バイオイメージング技術開発
渡邉朋信、市村垂生
生体の科学 65(5), 390-391 (Oct. 2014)

"Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles"
Taro Ichimura, Takashi Jin, Hideaki Fujita, Hideo Higuchi, Tomonobu M. Watanabe
Front. Physiol., fphys.2014.00273, 10.3389 (Jul. 2014)

2013年

生体分子動態のナノイメージング
渡邉朋信, 神隆, 市村垂生
光アライアンス 2013年4月号, 24(4), 15-20 (Apr. 2013)

超解像光学顕微鏡で観えるHIV-1の成熟過程
渡邉朋信
実験医学 2013年4月号, 31(6), 889-890 (Mar. 2013)

"Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators"
Kazunori Shimizu, Fujita Hideaki, Eiji Nagamori
J Biosci Bioeng, 115(2):115-121 (Feb. 2013)

2011年

"Thin filament-reconstituted skinned muscle fibers for the study of muscle physiology"
Sayaka Higuchi, Yoshikazu Tsukasaki, Noriko Fukuda, Satoshi Kurihara, Hideaki Fujita
Journal of Biomedicine and Biotechnology, 2011, 486021 (Nov. 2011)

著書

2016年


分化状態を可視化する非侵襲検査技術
市村垂生, 藤田英明, 渡邉朋信
iPS細胞の安全・高品質な作製技術(技術情報協会),6章6節,373-378 (Oct.31,2016)

1分子局在化顕微鏡の自作と撮像例
新井由之,市村垂生
初めてでもできる!超解像イメージング(岡田康志編,羊土社),実践編1章,48-67 (Jun. 2016)

蛍光相関超解像法SOFI ―自己明滅する蛍光プローブによる超解像
渡邉朋信、市村垂生
初めてでもできる!超解像イメージング(岡田康志編,羊土社),原理・応用編1章,250-256 (Jun. 2016)

2014年

1分子を見る光学顕微鏡
渡邉朋信、市村垂生
1分子生物学(原田慶恵・石渡信一編,化学同人),14章, 179-192 (Oct. 2014)

2012年

"CARS Microscopy: Implementation of Nonlinear Vibrational Spectroscopy for Far-Field and Near-Field Imaging"
Mamoru Hashimoto, Taro Ichimura, Katsumasa Fujita
Raman Imaging, Springer Series in Optical Sciences 168, 317-346
Springer-Verlag Berlin Heidelberg ( July,2012)

 国立研究開発法人理化学研究所
 生命機能科学研究センター
 先端バイオイメージング研究チーム

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